1) Neuroscience
- Genetic diseases -

- Methachromatic and Globoid cell Leukodystrophies (MLD and GLD) -
Hematopoietic stem cell (HSC) gene therapy approaches;
Combined gene and neural stem cell (NSC) based approach;
Safe standardized protocols for lentiviral-mediated gene correction.


2) Neuroscience
- Cancer -

-Isolation of tumour stem cells (TSCs) from medulloblastoma and glioblastoma;
-Generation of in vitro/in vivo models of brain tumours;
-Identification of genes involved in tumour initiation, progression, invasion and relapse.


3) Neuroscience
- Chronic inflammatory CNS diseases -
Neural stem cell transplantation for experimental multiple sclerosis (rodents and primates);
- Cerebrovascular diseases - (stroke)
Neural stem cell transplantation for experimental middle cerebral artery occlusion (MCAO) (rodents);
- Acute traumatic CNS injuries -
Neural stem cell transplantation for experimental acute spinal cord injury (SCI) (rodents).

Ophthalmology
- Retinitis pigmentosa -
- Macula degeneration -
stem cell therapy;
in vitro isolation;
differentiation into mature retinal cell types.

Chronic cardiac disease
Identification, clone expansion of self-renewing progenitors with high spontaneous cardiac differentiation.
Cell therapy approach for hereditary cardiomyopathy.

Type I diabetes
stem cells as alternative source of pancreatic b cells.
Stem cell sources:
-human amniotic fluid;
-adult pancreas (mouse and human).

Hematopoietic Stem Cells (HSC)
for oncohematological disorders Gene Therapy for oncohematological disorders.

Hematopoietic Stem Cells (HSC) for Genetic diseases:
-primary immunodeficiencies and thalassemia
-Transplantation of genetically modified HSC for ADA-SCID, WAS, MLD and thalassemia.

Muscolar dystrohy
Transplantation of mesodermal stem cells in order to promote muscle repair.
Mesoangioblasts as candidates for future stem cell therapy for Duchenne patients.